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In the forest plot, several studies including Harmony Outlets (2018), LEADER (2016), REWIND (2019), and SUSTAIN-6 (2016) appear to show a low risk of respiratory diseases

It appears to help stabilize blood sugar and gently reduce appetite, even in people without diabetes

For weight loss, the data puts retatrutide ahead: 24.2 percent at 12 mg over 48 weeks versus 14.9 percent for semaglutide at 2.4 mg over 68 weeks

Additionally, serious adverse events requiring emergent treatment, such as hypersensitivity reactions, occurred at a higher rate in patients receiving combination therapy [9, 26]

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Indeed, there is almost a complete overlap between NAFLD and MASLD populations in several epidemiological studies, while only 5.3% of individuals with NAFLD did not fulfil the MASLD criteria in the population-based Nutrition Examination Survey (NHANES III) [6, 8]