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In adipose tissue, the lipogenic effects of GIP appear to be context-dependent and influenced by insulin availability and metabolic status (35)

The expansion of BMAT under conditions such as caloric restriction may also play a role by altering the bone marrow niche and inhibiting osteoblastogenesis through adipocyte-derived cytokines

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They highlighted the need to consider potential tradeoffs between efficacy and side effects, finding that higher doses can have stronger efficacy but also induce more severe side effects

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