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As seen in Figure 1 and 2, there is a distribution of weight change after cessation of GLP1-RA therapy
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Ipamorelin acts as a ghrelin receptor agonist (GHS-R1a), with a different downstream signaling pathway and broader metabolic effects

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Why Earlier GLP-1 Therapies Changed Obesity Medicine The first major wave of GLP-1 therapies transformed obesity treatment by helping patients: Reduce appetite Improve satiety Lower caloric intake Improve glucose regulation For many patients, this produced substantial weight loss