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While most people tolerate them well, its helpful to know what side effects to expect, especially in the first few weeks of treatment: nausea vomiting diarrhea constipation headaches fatigue These symptoms are well-documented across clinical trials and often appear during the dose escalation phase

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Dehydration and vomiting can sometimes stress the kidneys

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Together, these actions: Reduce appetite and food cravings Help patients feel full longer Lower blood sugar levels in people with type 2 diabetes Because of these combined effects, semaglutide has become a powerful tool not only for diabetes care but also for long-term weight loss

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Patients must also take a trial of phentermine, an older drug chemically related to amphetamines and still widely used for weight loss, before they can be approved for GLP-1s

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