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In conclusion, compound 20 in the biphenyl-substituted triazole group, as well as compounds 21 and 22 in the acetoxy- and monophenyl-substituted triazole groups, demonstrated the highest potency for inhibiting DPP-4 (99) (Figure 4)

Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people

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Plaque Stabilization Preclinical studies on GLP-1 agonists show their ability to decrease macrophage infiltration while inhibiting foam cell formation and reducing matrix metalloproteinase-9 (MMP-9) expression, which helps create fibrous caps for plaque stability [24]

Despite the declines, GLP-1 users reported a continued desire to consume processed foods, sodas, refined grains and beef

In this regard, GLP-1RAs can provide the protection against VSMC senescence via increasing the nuclear factor erythroid 2-related factor 2 (Nrf2) activity [122]