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The intestinal absorption of glucose stimulates its secretion, which increases insulin and decreases glucagon secretion (27)

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Conversely, in a review of six clinical trials, researchers found that tirzepatide has a bigger impact on the absorption of oral contraceptives compared to other GLP-1s

In researchers with normal or low-normal blood pressure, the additive blood pressure lowering effect of combining both compounds may produce orthostatic hypotension or lightheadedness, particularly when standing quickly

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