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It has unique strengths and benefits: Significant A1C reduction and weight loss in Type 2 Diabetes (T2D) patients Safety profile of Orforglipron 3 mg, 12 mg, and 36 mg Tablets is similar to injectable GLP-1 drugs like Mounjaro or Zepbound Orforglipron 3 mg, 12 mg and 36 mg Convenience of daily oral administration It will likely be available in the following doses: Orforglipron 3 mg, 12 mg and 36 mg tablets Orforgliprons Significant A1C Reduction and Weight Loss in ACHIEVE-1 Study Image depicting the action of Orforglipton as a GLP-1 agonist Price: Will most likely vary by country, health system, and insurance status

For employers and health plans, this translates into improved adherence, reduced discontinuation, and better clinical and financial outcomes

Side effects are similar to other GLP-1 medications

The decrease in hyperglycaemia after administration of GLP-1 or GLP-1MK-801 was not associated with changes in plasma insulin levels (Extended Data Fig
