glp-1 cycling REPEATED USE MAY PROMOTE LONG TERM WEIGHT GAIN: A new mice study found exactly that. Repeated cycles of GLP-1's may have long term adverse effects on the very thing they were What are GLP-1s? | Mendinground
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Particularly, the background anti-diabetic agents, lipid-lowering drugs, antiaggregants, and antihypertensives may affect cardiovascular events

Intestinal release of GLP-1 augments initial insulin secretion in vivo in part through a vagal-vagal reflex leading to cholinergic stimulation of islet beta cells

If needles are the reason you have avoided GLP-1s, Shed is the lists best fit

Clin Endocrinol (Oxf)

A key marker of oxidative stress is AOPPs, plasma byproducts of oxidative stress [58], which are elevated in diabetic patients and contribute to diabetic nephropathy by increasing proinflammatory molecules such as NADPH oxidase, NF-B, and ROS [56]
