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Persistent fatigue beyond 68 weeks is uncommon and usually signals an underlying issue such as inadequate protein intake, dehydration, or undiagnosed low iron levels rather than the medication itself

Preclinical studies in rodents have also shown a relationship between GLP-1 RAs and the development of thyroid c-cell tumors, including medullary thyroid carcinoma (MTC)

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Variants in genes controlling creatine transporter (SLC6A8) and muscle phenotype influence whether supplementation meaningfully preserves lean mass during caloric restriction
