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For AUD or smoking indications, expect prior-authorization denials until FDA labeling changes

Effects of GLP-1 agonists on vascular endothelium Enhancing endothelial function A review of the literature revealed multiple preclinical studies on GLP-1R agonists in animal models demonstrating the molecular mechanisms behind their pharmacological effects

Higher doses generally resulted in a higher rate of side effects

Side Effects and Safety Can increase the risk of urinary tract infections, dehydration, and genital infections

Behavioral and mental health support Some GLP-1 users experience emotional challenges after discontinuing treatment or during rapid body change

The corresponding references for the induced cardiomyopathy models discussed above are summarized in Table 3 (Ref