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Randomized clinical trials (RCTs) are the optimal studies for determining cause and effect relationships

GLP-1 is also implicated in regulating hedonic eating through GLP-1Rs located elsewhere in the brainstem (98100)

The link to AD was previously implicated through its association with T2DM, where insulin receptors and signaling were found to be similarly desensitized between both conditions [59]

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Among those who had a measurement, the absolute change was calculated as the difference to the last value available before treatment initiation in mmol/mol for HbA1c, mL/min/1.73 m 2 for eGFR, and mmol/L for lowdensity lipoprotein (LDL) cholesterol, and triglycerides

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