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Sulfonylureas such as glibenclamide exploit this mechanism therapeutically, and recent evidence indicates that glibenclamide also agonizes the TRPA1 ion channel, suggesting previously unrecognized interactions with sensory ion channels [19]

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Clinical trials with semaglutide have demonstrated significant potential to treat diseases of the brain, liver, heart, vascular system (veins and arteries), lungs, bones, skin, and kidneys [1,4], and this class of drugs also shows promise for treating arthritis [1,5]