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A recent meta-analysis of Phase 3 trials reported increases in HR, based on single time point assessments, in the range of 14 bpm with both long- and short-acting GLP-1 RAs [15]

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Peripheral but not central administration of GLP-1 fails to inhibit angiotensin (ANG) II-induced drinking in rats that have been treated with monosodium glutamate (MSG) to induce damage of the ARC and the sensory circumventricular organs, suggesting that peripherally administered GLP-1 effects drinking behavior via CNS-dependent mechanisms [760]

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