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EMPA-REG not only showed that empagliflozin was safe, but it also showed a stunning, and largely unexpected, reduction in CV mortality, heart failure admissions, and total mortality (Figure 3)

Future studies should explore depressive symptoms in diabetes patients treated with anti-inflammatory agents, particularly in comorbid populations

Zepbound is also approved to treat moderate to severe obstructive sleep apnea in adults with obesity

In guidance published in March 2023, NICE approved semaglutide for NHS treatment for weight loss, saying at the time that the drug would be available soon

Get weekly health news While obesity has been framed as a lifestyle choice or a consequence of a lack of willpower, doctors are increasingly understanding the disease as a chronic, life-long condition potentially influenced by hormones, physiology, mental health and environmental factors like racism and poverty

These symptoms develop over hours to days and typically worsen without treatment