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Description
The two brands differ in FDA-approved indication only: Zepbound is approved for chronic weight management and sleep apnea in obesity, while Mounjaro is approved for type 2 diabetes

The MHRA and EMA include pancreatitis warnings in prescribing information, though current evidence suggests benefits generally outweigh risks in appropriately selected patients

Certificate available upon request

Surgical procedures: Inform your surgical and anaesthetic teams about GLP-1 receptor agonist use before any planned procedures, as these medications may affect gastric emptying and potentially increase aspiration risk
Ponirakis G, Abdul-Ghani MA, Jayyousi A, Zirie MA, Qazi M, Almuhannadi H, Petropoulos IN, Khan A, Gad H, Migahid O, Megahed A, Al-Mohannadi S, AlMarri F, Al-Khayat F, Mahfoud Z, Al Hamad H, Ramadan M, DeFronzo R, Malik RA (2021) Painful diabetic neuropathy is associated with increased nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control

Research since 2023 has shown improvements in ovulation and menstrual regularity for some patients using GLP-1s (Escobar-Morreale et al., 2024)
