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Unfortunately, during this transition period, there is often delayed or inappropriate care, improper timing of the transfer of care, and undue emotional and financial stress on the patients, their families, and the healthcare system

In addition, it can activate AMPK and PI3K/Akt signaling pathways and promote autophagy, thus improving cognitive function [36]

Concomitant use of weight-promoting medications, such as insulin or sulfonylureas, may further blunt the weight loss effects of GLP-1 RAs [45]

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Developmental origins of diabetes mellitus: environmental epigenomics and emerging patterns

In clinical settings, a separate study showed that GLP-1 infusion significantly improved endothelial function in patients with type 2 diabetes and coronary artery disease, reinforcing the microvascular potential of this class