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While all four of these trials did enroll patients with established ASCVD, the SELECT trial showed benefit for patients with no history of T2DM
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& Giordano, C

Guivarch PH, Castaigne JP, Gagnon L, Peslherbe L, Dreyfus JH, Drucher DJ

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

They also assessed the proportion of people in each group who hit the goal of losing 5% or more of their body weight over the study period
