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Conclusions/interpretation Progression to diabetes explained less than one-quarter of the risks of clinical outcomes associated with prediabetes

In new guidelines, the American Society of Anesthesiologists (ASA) and other professional groups recommend that most patients using glucagon-like peptide-1 (GLP-1) receptor agonists can continue their medication regimen prior to elective surgery

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Key implications: Simplified administration may improve patient uptake Broader accessibility across diverse healthcare settings Reinforces the shift toward chronic disease models in obesity care As we move forward, the focus will not only be on efficacy but also on real-world implementation, cost considerations, and long-term outcomes

Though newer GLP-1 analogs have taken center stage, DPP-4 inhibitors were the first incretin-based therapies that paved the way for todays metabolic revolution