half life of glp 1 agonists GLP-1 receptor in the treatment type 2 diabetes – state-of-the-art Battle of GLP-1 delivery technologies
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PMID 33567185
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Semaglutide is started at 0.25 mg weekly, then 0.5 mg after 4 weeks, and then 1.0 mg after another 4 weeks to mitigate nausea
While short-term efficacy is well-documented, concerns remain about the long-term impact of prolonged GLP-1 receptor activation, particularly in non-diabetic populations
& Merchenthaler, I
