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En coherencia con las observaciones realizadas en los modelos in vitro, diversos hallazgos apoyan la hiptesis de que los efectos cardioprotectores de GLP-1 (7-36) en modelos de isquemia-reperfusin estn mediados por la activacin de quinasas de la va RISK, entre ellas PI3K, ERK1/2, cAMP, PKA, Akt y P70S6K (tabla 2)29,34,42,49,50,5255