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In some patients, lack of volume and fat loss in the area may lead to a sunken appearance beneath the eyes

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

doi: 10.1093/ckj/sfae296

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Here is the "real talk" I have with my clients every day: that slowed-down digestion is a double-edged sword

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