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This is particularly due to its association in the increased incidence of endometrial lesions (including hyperplasia, carcinomas, and sarcoma) found in women undergoing chronic treatment with tamoxifen
Int J Dermatol 58(10):12021204

If needles are the reason you have avoided GLP-1s, Shed is the lists best fit

Glucagonlike peptide 1 (GLP1): an intestinal hormone, Signalling nutritional abundance, with an unusual therapeutic potential

This recommendation is based on the considerable body of evidence that has accumulated over the last 30 years, but it is also supported on clinical grounds based on metformins affordability and tolerability
