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Bottom Line GLP-1 agonists have a place in medicine as treatment for Type 2 diabetes and obesity, offering benefits in blood sugar control and weight loss

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But what we are, there are two sides of low

In individuals with obesity and diabetes, the incretin effect is diminished, contributing to poor glucose tolerance

The CMS said it will release additional details on participation in early 2026

Another important consideration when evaluating the impact of these medications on bone health outcomes is the sustainability of GLP1Ra use as weight regain following cessation of treatment is expected (Quarenghi et al., 2025)