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In addition to vascular protective effects, GLP-1R agonism improves experimental heart failure across several species, including mice (2132), rats (3337), pigs (38, 39), and dogs (40, 41) (Figure 2)

doi: 10.1016/j.clpt.2005.09.002

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Metabolic risk in patients with IBD While evidence remains mixed regarding the direct impact of obesity on IBD disease activity, the literature consistently demonstrates that obesity is associated with an increased risk of surgical complications, 104 particularly post-operative infections where a systematic review found an odds ratio of 1.48 compared to non-obese patients with IBD, technical challenges in the creation of an ileal pouchanal anastomosis or stoma 105 and parastomal hernia development

A succinct summary of GLP-1 medications, their therapeutic value, and possible side effects is available here

Employers must vet compounding pharmacies thoroughly and require third-party testing and documented employee consent