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And the study protocol registered to UMIN-CTR (No.UMIN000024556) approved by International Committee of Medical Journal Editors (ICMJE)

Better tolerability with lower nausea rates (25%)

Contraindications Data from rodent studies of GLP-1-mediated thyroid C-cell hyperplasia indicates that use is contraindicated in people with a personal or family history of medullary thyroid carcinoma or with multiple endocrine neoplasia type 2.

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Heo S, Lennie TA, Okoli C, Moser DK (2009) Quality of life in patients with heart failure: ask the patients