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Macrodosing prioritizes therapeutic outcomes that are measurable on a clinical scale
NHS prescribing data, Clinical Practice Research Datalink) cannot be relied upon to provide accurate estimates

Semaglutide oral is co-formulated with sodium N-(8-[8-[2-hydroxybenzoyl]amino) caprylate (sodium salcaprozate or SNAC) which allows absorption of semaglutide across the gastric mucosa

Model medication levels from half-life, logged doses, and scheduled doses to estimate usual level and on-board carryover

Hauge-Evans et al., 2009
