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It is usually easy to diagnose anterior versus posterior epistaxis with direct visualization

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Across completed head-to-head randomized trials, tirzepatide consistently achieved greater reductions in body weight, and HbA1c than semaglutide in individuals with obesity or T2DM
doi: 10.1016/S2213-8587(21)00314-4

Der Spiegel

Case reports link tadalafil to NAION, characterized by painless unilateral visual loss and optic-disc edema, most often within 24-48 hours of dosing