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The Agencys Center for Drug Evaluation and Research (CDER) has accepted a Letter of Intent for use of liver stiffness measurement by vibration-controlled transient elastography (VCTE) as a reasonably likely surrogate endpoint for all-cause mortality or liver-related events in adults with non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver fibrosis

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6.1.2 Omega three (DHA/EPA) Omega three (DHA/EPA) is being studied in a Phase 3 trial of 400 participants who have a low red blood cell DHA/eicosapentaenoic acid (EPA) index, subjective memory complaints, and a family history of AD (NCT03691519)

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Dosage form optimization: Controlled-release formulations enabling once-weekly oral administration Indication expansion: NASH, Alzheimers disease, cardiovascular protection Conclusion: A game-changing Molecule Design Orforglipron represents a triumph in small molecule drug designit demonstrates that clever chemical structure design can break through the dominance of biologics

Three-dimensional structures of curcumin (enol and diketone forms) were obtained from ZINC15, a free database of commercially available compounds for virtual screening 55