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In addition, yerba mat inhibited hepatic Tnf- and restored hepatic and muscle insulin signaling through an increase in IRS-1 tyrosine phosphorylation in mice with high fat diet-induced obesity [45]

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A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II) Obesity (Silver Spring) 2013;21(5):935943

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