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As of early 2026, the FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list after stating it did not identify a clinical need for outsourcing facilities to compound those drugs from bulk substances

Kosinski M, Bayliss MS, Bjorner JB, et al

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Companies such as AstraZeneca are also working on injectable drugs targeting the hormone amylin for enhanced weight-loss regimes, combining different drugs and medicines designed to preserve muscle mass

Some people experience gastrointestinal changes as gastric emptying rate returns to normal
