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These results prompted the hypothesis on a direct role of GLP-1 in controlling pubertal development through the hypothalamic GnRH secretion, although this mechanism still remains to be unraveled

Nevertheless, a retrospective analysis of T2DM treatment in UK showed that the mean time to add a second oral agent in patients with A1c above 7.0, 7.5 and 8.0%, was 2.9, 1.9 and 1.6 years, respectively

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However, researchers suggested that this difference could be explained by 50% of the patients discontinuing their treatment during the first year, and 80% taking lower dosages

Qualifying comorbidities include type 2 diabetes, hypertension, dyslipidemia (abnormal cholesterol levels), and obstructive sleep apnea

Addressing barriers such as cost, long-term adherence, and patient selection criteria will be essential to optimize their integration into clinical practice