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DPP-4 inhibitors double the circulating concentrations of both GLP-1 and GIP

Marso SP, Bain SC, Consoli A et al

Some individuals, particularly those with a history of eating disorders or disordered eating patterns, may find that the profound appetite suppression from both medications triggers or worsens problematic behaviours around food

Solutions could include reducing prices or expanding patient assistance programs

As with Saxenda, people taking liraglutide should also eat a reduced-calorie diet and get regular exercise

Co-administration leads to greater reductions in albuminuria and more pronounced initial declines in eGFR, indicative of reduced intraglomerular pressure [122,123]