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The GLP-1 resistance in diabetic conditions is thought to be caused by the downregulation of the GLP-1R caused by PKC overexpression and the decreased GLP-1 post-receptor anti-apoptotic signaling pathways caused by PKC overexpression [83]
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Compounded semaglutide from licensed 503A pharmacies contains the same active ingredient as Wegovy and works through identical biological mechanisms

Important Considerations for Lymphedema Therapists As GLP-1 medications become increasingly common, therapists should be prepared to discuss them with patients
