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Big compounders will have until May 22 to stop producing and dispensing compounded semaglutide, while smaller, state-run pharmacies must immediately stop making copies of the blockbuster drug.

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GLP-1 drugs like Ozempic, Wegovy, and Mounjaro and the gut microbiome influence each other in both directions

In todays newsletter: A new study shows that people dont just regain weight after stopping GLP-1 drugs, they see other positive health markers reverse leading to questions about long-term impacts and solutions

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We don't have good data on: *What outcomes look like at various sub-therapeutic doses *Which patients might benefit from lower, more frequent dosing versus higher, less frequent *How hormonal changes (hello, perimenopause) affect optimal dosing *Long-term effects of maintenance microdosing after weight loss goals are met The doctor quoted in the article is right that standard doses exist because they've been proven effective