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Weiss T, Carr RD, Pal S, et al

One particularly notable case report described a 23-year-old female who developed alopecia areata, an autoimmune form of hair loss, just two months after starting semaglutide

In that study, the glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to initiate a regulatory program driving an early transcriptional activation of metabolic genes, which is followed by a second wave of transcriptional regulation wherein cell-cycle genes are activated and -cell identity genes are repressed

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