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The etiopathogenesis of HS is complex and poorly understood

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Moreover, the hypophagic effects of the GLP1 agonists were blunted by administration of GLP1 receptor antagonists into the brain ventricular system (i.c.v

In the SELECT trial, 2.4 mg semaglutide weekly or placebo was administered to over 16,000 patients with overweight/obesity and established cardiovascular disease (85)

It mimics a naturally occurring hormone in the body called glucagon-like peptide-1 (GLP-1)