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In some patients, gastrointestinal side effects can be severe enough to lead to treatment discontinuation
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By stably linking estrogen to GLP-1 in a single molecule, this coagonist can take advantage of estrogen's effects on weight loss while avoiding the negative side effects on other tissues (Finan et al., 2012)
By influencing brain signals, GLP helps reduce hunger and increase feelings of fullness
Random effects or fixed effects model was conducted based on the heterogeneity among trials
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