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With respect to GLP-1RAs, liraglutide and semaglutide have demonstrated a reduction in the risk of major adverse cardiovascular events (MACE) [16, 17], and, while yet not published, early reports for dulaglutide indicate CV benefits in patients with a wide range of CV risk [18]

On further probing Madsen found that the tumours secreted an abundance of GLP-1, which he published in a paper together with Holst and others in 1995 (Blume, Skouv, Larson)

Dose titration with the glucagon-like peptide-1 agonist, liraglutide, reduces cue- and drug-induced heroin seeking in high drug-taking rats

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The resulting increase in GABA release helps restore the balance of excitatory and inhibitory neurotransmission by decreasing glutamate activity, promoting neuronal survival, and enhancing mitochondrial function