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On the other hand, patients receiving tirzepatide did not have significantly different triglycerides and LDLc compared with GLP-1RAs (i.e., dulaglutide/semaglutide) [94], but had significantly higher HDL-c compared to dulaglutide/semaglutide + 0.72 mg/dL [50]
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Comparative studies have shown that Tirzepatide outperforms Semaglutide in improving glycemic control and achieving greater weight reduction, as demonstrated in the SURPASS-2 (NEJM 2021) trial
Nutrients 12 , 15 (2019)
