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doi: 10.1016/j.celrep.2019.07.043

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GLP-1 Receptor Agonists (e.g., semaglutide, liraglutide) Increase insulin secretion in response to food Reduce glucagon release (which lowers blood sugar) Slows gastric emptying (which helps with post-meal glucose excursions) Reduces appetite and induces satiety which leads to weight loss GLP-1/GIP Receptor Agonists (e.g., tirzepatide) GLP-1 effects (same as above) GIP effect: further enhances insulin secretion Both medications help with blood sugar control and weight loss, but Mounjaros dual mechanism may offer stronger effects on insulin secretion, which improves A1c levels

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