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Is the stepping-down approach a better option than multiple daily injections in obese patients with poorly controlled Type 2 diabetes on advanced insulin therapy
3.2 From single-target optimization to rational polypharmacology Another major shift influencing the relevance of underexplored peptide systems is the growing acceptance of rational polypharmacology
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The TH mimics-induced improvement in glucose homeostasis was usually considered to be secondary to weight loss 17
Furthermore, the two groups had no evidence of a difference in mortality rate (HR 1.06
