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GLP-1 medications carry a boxed warning in the United States for the risk of thyroid C-cell tumors, based on rodent studies in which prolonged GLP-1 receptor stimulation led to tumor formation
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References: Hohman, M
Diabetes Obes Metab 2010;12(5):384392
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In addition, neither electrophysiological administration of PYY, melanotan II, nor ghrelin stimulates these neurons in isolated NTS brain slices [351]
