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In concrete numbers, this means that 1 in 8 American adults has been estimated to have tried the drug to date
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For persistent symptoms, intra-articular corticosteroid injections or duloxetine may be appropriate adjunctive therapies
These agents require careful dose titrations due to their adverse drug event (ADE) profile, which commonly includes nausea and vomiting
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Nausea, diarrhea, and vomiting most common
