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Safety profiling of GLP-1 therapy Studies have found that GLP-1 agonists are associated with increased risk of gastrointestinal adverse events spanning from nausea and vomiting to pancreatitis and kidney dysfunction

Of particular interest are the paracrine effects of adipokines and gastrointestinal substrates regulated by DPP-4, such as leptin, adiponectin, pancreatic peptide YY (PYY), and glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2 (GLP-2), which may mediate the crosstalk between bone remodeling and energy metabolism [2, 24]

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Drug-induced lupus erythematosus: an update on drugs and mechanisms

Mayer, F., Gunawan, A

Does GLP-1/glucagon co-agonism offer long-lasting and enhanced efficacy for lowering blood glucose over that of GLP-1 analogues alone
