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GLP-1 analogs on beta-cells: Glucose dependent insulin secretion For nearly 2 decades now, GLP-1 has been heavily investigated as the most promising therapy target in type 2 diabetes patients

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Interestingly, certain classical inflammatory stimuliincluding lipopolysaccharide (LPS) and pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) can, in turn, induce GLP-1 secretion