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Acknowledgements This work was supported by the National Research Foundation (NRF) via the Creative Research Initiative Center (Grant number: NRF-2015 R1A3A2066191), Republic of Korea

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[20] Patients should be aware of red flags requiring medical attention, including severe persistent abdominal pain (possible pancreatitis), severe or persistent vomiting leading to dehydration, symptoms of gallbladder disease, vision changes, or allergic reactions

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Typical mild reactions peak within 24 to 72 hours and usually improve with simple care, whereas spreading redness larger than a few inches, fever, or breathing difficulty requires urgent evaluation