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The analgesic effects of liraglutide were not observed in mice with constitutively active glycogen synthase kinase-3 beta (GSK3), as activation of GSK3 promotes the activation of the NLRP3 inflammasome [48]

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Interestingly, the enhanced insulin-mediated glucose disposal was attributed to a greater degree of glucose uptake into adipose tissue but not skeletal muscle

V.MeenakshiS.SrivijayanA.ThiruselvamS.et al (2025)

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The diagram above illustrates how a DVT forms in the leg vein