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The clinical relevance of gastrointestinal adverse events associated with GLP-1 RAs depends not only on their incidence but also on their severity, duration, and impact on patient quality of life

These decisions will centre on positioning new entrants, whether off-patent semaglutide or next-generation obesity medicines, in an increasingly crowded field

It is typically administered as a once-weekly injection through your prescribing provider

Semaglutide works on one receptor, the GLP-1 receptor

In some cases, this leads to therapeutic compromises, where treatment decisions are shaped by access rather than optimal efficacy

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