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When oxidative demand approaches or exceeds the regenerative capacity of NAD + /NADPH-dependent buffering systems, a conditional rate-limiting stateconceptualized here as a redox bottleneck may emerge

Key end points included: hospitalisation, heart failure (ICD-10-CM-I50), myocardial infarction (ICD-10-CM-I21), stroke and transient ischaemic attack (ICD-10-CM-I63, G45), development of diabetic microvascular complications (ICD-10-CM-E10.210.4) and all-cause mortality analysed 3 months to 5 years post drug initiation

10.1016/j.jhep.2015.08.038 6 ArvanitakisK.KoufakisT.KotsaK.GermanidisG

The emerging role of polyphenols in the management of type 2 diabetes

There is no way to rescue it
These potential shifts include: Passing legislation like the Treat and Reduce Obesity Act, which would allow Medicare to cover obesity medications
