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For AD, brain tau levels as measured by PET are also being evaluated as a response biomarker, but the evidence from past clinical trials of anti-amyloid antibody treatments regarding the ability of tau-PET to reflect clinically meaningful intervention effects has been mixed (Aisen et al., 2021

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The GLP-1R is expressed in various tissues, including but not limited to pancreatic -cells, various cell types of the gastrointestinal tract, neurons throughout the peripheral and central nervous system (CNS), the kidney, the vasculature, and the heart [8,9,10]